Pathology 1

Course
Semester
Spring
Year
2022
Faculty and Staff Information
  1. Course Director:
    1. Dr. Brian Butler, DVM, MPH, PhD, Dipl. ACVP, Professor
    2. Email: bbutler@sgu.edu
    3. Office Location: SVM trailer
    4. Office Hours: by appointment
  2. Additional faculty:
    1. Dr. David Marancik, DVM, PhD, Associate Professor, dmaranci@sgu.edu
    2. Dr. Melinda Wilkerson, DVM, PhD, Dipl. ACVP, Professor, mwilkers@sgu.edu
  3. Staff members:
    1. Ms. Cindy Edwards, Executive secretary, cedwards@sgu.edu
    2. Mr. Ferron Victor, Laboratory technician (A/V support)
    3. Ms. Veronica Mapp-Alexander, Laboratory technician (Histology lab)
Course Location

Online and In-person. Course content will be delivered via My Courses, Panopto, Zoom, and TopHat.

Required Resources

All course materials are provided in My Courses > Resources and Assignments. Links will be provided for all Panopto, Zoom, and TopHat content. A functional computer with microphone and camera is required for proctored remote examinations.

Recommended Resources

Textbook: Pathologic Basis of Veterinary Disease, 6th edition. Zachary and McGavin. 2016.

Accommodation
  1. Students with disabilities who may require accommodations should contact Student Accessibility and Accommodations Services (SAAS), located in the Dean of Students Office.
  2. Information can be found at mycampus.sgu.edu/group/saas
Other Requirements

None

Course Rationale

Pathology I is a 4-credit course composed of didactic lectures mixed with active learning exercises, formative assessment, and interactive clinical case investigations. In addition, there are two laboratory sessions that utilize small group exercises and hands-on learning opportunities with animal tissues and/or simulations. This course serves as an introduction to the discipline and clinical service of veterinary pathology. Term 3 DVM students are expected to integrate knowledge from multiple disciplines (anatomy, physiology, embryology, histology, microbiology, virology, parasitology, etc.) and develop their aptitude for conceptual learning and problem-based medicine. During the first half of the course, students will learn the fundamental mechanisms of tissue injury and disease (General Pathology). The second half of the course will take a systematic approach focused on individual organ systems and their respective diseases in domestic species (Systems Pathology). This latter portion of the course will utilize “flipped classroom” techniques and participants will cover course content through student-directed learning in the form of prescribed lessons, assignments, and review papers. In addition, students will spend in-class time with the instructor focused on content review and formative assessment in preparation for exams. The remaining sections of Systems Pathology are covered in the Term 4 course, Pathology II. In addition, students will also receive an introduction to the clinical service of diagnostic pathology and the relevance of this service to their clinical careers.

Course Learning Outcomes

The emphasis of this course is placed on the training and development of clinical proficiency, and thus, the course material and the course goals are focused on learning the pathogenesis and pathophysiology of the most important veterinary diseases of domesticated animals. The overall goal of this course is to provide students with a solid understanding of veterinary disease as it relates to lesion development, clinical signs, diagnostic strategy, and clinical outcomes.

Upon successful completion of this course, the student will be able to…

  1. Apply a working vocabulary for the language of pathology and know how to use pathological terminology correctly. Practice communication skills as they relate to the language of pathology in a clinical setting.
  2. Examine the principle mechanisms of disease at the whole body, cellular, and molecular levels (general pathology). Integrate knowledge about the principle mechanisms of disease into clinical case-based scenarios.
  3. Recognize, describe, and interpret gross lesions and limited histological lesions.
  4. Given a lesion and patient history, formulate a morphologic diagnosis, comprise a list of differential diagnoses, and determine the most likely etiologic diagnosis.
  5. Given a specific disease, determine the range of ancillary diagnostic tests that are required to reach a definitive diagnosis.
  6. Examine the development of lesions (pathogenesis) by identifying the basic mechanisms of injury and tissue responses.
  7. Correlate lesions with clinical signs (pathophysiology), patient history, and clinical laboratory data.
  8. Compare and contrast the commonalities and discrepancies of lesions and disease mechanisms across species (comparative pathology).
Lesson Learning Outcomes

Lec.

Topic

Learning Outcomes

CLO

1

Introduction to pathology

  1. Demonstrate a general understanding for the discipline and specialty practice of pathology.
  2. Review and define specified terms relating to pathology.
  3. Review and explain the concept of pathogenesis.
  4. List a chronologic sequence of events for a specific veterinary disease (stepwise list of pathogenic events).
  5. Review and explain the concept of a pathognomonic lesion and provide examples in veterinary medicine.
  6. Discuss the relationship of pathology to clinical medicine (pathophysiology) and review the different types of diagnoses.
  7. Discuss the wide range of career opportunities offered in pathology.

1

 

 

 

 

1

 

 

1,6

 

 

6

 

 

 

1

 

 

 

1,7

 

 

 

1,4,5

2

Cellular injury, adaptation, and death Part 1

  1. Differentiate the causes and consequences of cellular injury to cell membranes, mitochondria, and the nucleus.
  2. Describe the process of oxidative injury to cellular components and evaluate the overall significance of oxidative stress in the pathogenesis of disease.
  3. Explain the causes and consequences of DNA damage to the cell, and to the organism.
  4. Explain the causes and consequences of DNA damage to the cell, and to the organism.
  5. Explain the causes and consequences of the different types of physical injury to cells.

2

 

 

 

 

 

 

2

 

 

 

2

 

 

 

2

 

 

 

2

3

Cellular injury, adaptation, and death Part 2

  1. Compare the mechanisms and outcomes of reversible and irreversible cell injury.
  2. Describe the causes and mechanisms of cell swelling (hydropic degeneration).
  3. Describe the mechanisms, morphologic features, and sequelae of necrosis.

1,2

 

 

 

1,2

 

 

1,2

 

 

1,2,3

 

 

  1. Describe the mechanisms, morphologic features, and sequelae of apoptosis.
  2. Compare and contrast the different mechanisms and outcomes for cellular adaptation to chronic injury.

 

1,2,6,7

4

Fluid balance and disturbances of blood flow

  1. Review structural and functional characteristic of arteries, capillary types, venules, and lymphatics that maintain the circulatory system.
  2. Apply concepts of Starling’s law of forces to explain how differences in pressure gradients (hydraulic and colloid oncotic pressure, COP) in the capillaries maintain fluid within the capillaries or cause edema. Describe differences in glomeruli and liver (permeability of proteins).
  3. Describe four alterations in capillary dynamics that cause edema and list the causes.
  4. Recognize and describe the gross and histopathologic appearance of edema.
  5. Explain how pulmonary edema, pleural and peritoneal effusions occur.
  6. List and describe the different types of cavitary effusions and recognize the

pathophysiology of each type.

1,2

 

 

 

 

 

 

2,3,6

 

 

2,6

 

 

2,3,6

 

 

2,6

5

Hemostasis and Thrombosis

  1. Describe the role of primary and secondary hemostasis and the types of hemorrhage that occur when there are defects in each.
  2. Identify proteins important for primary hemostasis and identify vitamin K dependent coagulation factors.
  3. Describe causes of thrombus formation (Virchow’s triad).
  4. Describe the different types of thrombi (arterial and venous), their removal process from vessels, and consequences of recanalization.

1,2,6

 

 

 

 

2,7

 

 

 

2,6

 

 

2,6

 

 

2

 

 

 

2.7

 

 

2,3,6,7

6

Inflammation (1) Introduction to inflammation

  1. List the causes of inflammation and compare and contrast how each varies in their pathologic presentation.
  2. Recognize that inflammatory lesions by applying the Cardinal Signs of Inflammation.

1,2,6

 

 

1,2,6

 

 

2,6

 

 

3.  Describe how the vascular system responds

after an inflammatory insult and apply this to the clinical presentation.

 

7

Inflammation (2) Cellular mediators

  1. Review the categories of inflammatory cells and how to differentiate them based on morphology.
  2. Describe the unique features of inflammatory leukocytes and understand how they contribute to the inflammatory process.
  3. Be able to interpret what the presence of each cell type tells you about the inflammatory response.

1,2

 

 

1,2,6

 

 

3

8

Inflammation (3) Chemical mediators

  1. Categorize each major system and discuss the mediators that have been highlighted.
  2. Distinguish how each system contributes to inflammation and/or resolution of inflammation.
  3. Illustrate how these systems are intertwined and connected.

2

 

2,6

 

 

2,3

9

Inflammation (4)

  1. List each type of exudate and describe it’s chemical, cellular and fluid composition.
  2. Recognize each exudate grossly and microscopically.
  3. Compare and contrast what each exudate tells you about the inciting cause, how it’s helpful and/or harmful to the body, and how it’s resolved.
  4. Correctly use the specific terminology involved in describing exudates.

1,2,6

 

Exudates

 

 

 

2,3,6

 

 

6,7

 

 

 

4,6

10

Inflammation (5)

Morphologic diagnosis

  1. Accurately evaluate gross and microscopic

changes in the tissue and develop a correct morphologic diagnosis.

1,2,3,4

11

Inflammation (6) Healing and repair

  1. List the beneficial effects of inflammation and the harmful effects of inflammation.
  2. Summarize and understand the four types of hypersensitivity diseases.
  3. Explain the mechanisms necessary for tissue repair.

1,2,7

 

 

2.6

 

 

2,6

12

Inflammation (7) Healing and repair

  1. Categorize how tissue repair differs depending on tissue type and injury.
  2. Describe when and how fibrosis occurs.
  3. Recognize potential complications that can hinder effective healing.

1,2,6,7

 

 

2,6

6,7

13

Inflammation (8)

Case Study 1

  1. Evaluate a clinical case scenario.
  2. Integrate your knowledge of inflammation to explain disease pathogenesis, pathophysiology, prognosis, and treatment.

1,2,3,6,7

14

Inflammation (9)

Case Study 2

  1. Evaluate a clinical case scenario.
  2. Integrate your knowledge of inflammation to explain disease pathogenesis, pathophysiology, prognosis, and treatment.

1,2,3,6,7

1,2,3,6,7

15

Inflammation (10) Review with active learning

  1. Review important concepts of inflammation.

6,7

16

Neoplasia (1)

  1. Identify/recognize the types of growth disturbances that may precede neoplasia and the possible mechanisms/causes of these growth disturbances.
  2. Given morphologic descriptions (written/pictures) of these growth disturbances, identify likely clinical presentations associated with them.
  3. Given descriptions of clinical presentations, identify from a list the most likely of these growth disturbances responsible for the clinical presentation.

1,2,6

 

 

 

1,2,3,6,7

 

 

 

1,2,7

17

Neoplasia (2)

  1. Given the gross and microscopic description (written and in pictures) of a tumor be able to recognize the name/classification of the tumor and be able to differentiate between benign and malignant tumors.
  2. Given the name of a tumor and other relevant tumor diagnostic data, be able to recognize its characteristics, including its expected clinical behavior and possible causes, risk factors and metastatic potential and metastatic pathways.
  3. Recognize the stages of initiation, promotion and progression of neoplastic transformation.

1,2,3,6

 

 

 

 

1,2,6,7

 

 

 

 

1,2,6

18

Neoplasia (3)

  1. Given a description of a possible mechanism of carcinogenesis, be able to distinguish between genetic and epigenetic involvement
  2. Be able to identify the primary genetic targets involved in carcinogenesis.
  3. Be able to distinguish between the tumor parenchyma and stroma and the importance of tumor stroma on the clinical presentation and behavior of a tumor.

1,2,6

 

 

 

2

 

 

2,6

19

Neoplasia (4)

  1. Given a clinical scenario (species, age, breed, sex, husbandry, symptoms, tumor type, etc.) be able to identify possible cancer risk factors and/or possible causes.
  2. Be able to distinguish among the mechanisms of carcinogenesis causes by chemical, physical and microbial agents.
  3. Given a clinical scenario and tumor type, be able to recognize possible direct and paraneoplastic effects of the tumor on the host.

1,2,7

 

 

2

 

 

2,7

20

Neoplasia (5)

  1. Recognize evidence in support of both innate and acquire immune responses to transformed cells.
  2. Understand the concept of tumor antigen and be able to Identify the major innate and acquired immune mechanisms that target transformed cells and those with current/potential use in immunotherapy.
  3. Recognize the mechanisms tumors use to evade immune detection and immune responses.

2,6

 

 

2

 

 

 

2,6

21

Infection (1)

  1. Review and classify the types of inflammation that are associated with different infectious organisms.
  2. Evaluate and understand the basic concepts of infectious disease pathogenesis.
  3. Evaluate and understand the mechanisms of virulence, host response, and lesion morphology, and clinical significance of viral, bacterial, fungal, protozoal, and prion diseases.

1,2,6

 

 

1,2,6

 

1,2,3,6,7

22

Infection (2)

  1. Identify and analyze the pathogenesis and clinical significance of coinfections and infectious disease complexes.
  2. Identify and analyze the pathogenesis and clinical significance of oncogenic infections.
  3. Analyze the pathogenesis and importance of dysbiosis as it relates to inflammatory diseases.
  4. Determine effective ways to stay current on emerging infectious diseases.

1,2,6,7

 

 

1,2,6

 

1,2,6

 

 

1,2

23

Gross Pathology

  1. Discuss the clinical importance of the postmortem examination.

1

 

1,3

 

 

  1. Review the complete step-wise process of the postmortem examination (necropsy technique).
  2. Identify and classify postmortem tissue changes.
  3. Identify all of the required descriptive features for gross lesions.
  4. Practice generating morphological diagnoses for described lesions.
  5. Discuss the importance of ancillary testing and analyze how to use gross findings to guide ancillary tests.

 

3

 

1,3

 

1,3,4

 

1,5

24

Surgical Pathology

  1. Discuss the clinical importance of surgical pathology.
  2. Review the process of biopsy sample collection and submission to the lab.
  3. Determine which components of the biopsy report are critical to the clinician.
  4. Examine and understand the techniques which are used to evaluate surgical margins.
  5. Evaluate the importance and clinical relevance of histologic grading of tumors.

1,7

 

1

 

1

 

1

 

1

25

Urinary (1)

  1. Review renal physiology and examine which structures of the kidney are most vulnerable to various types of injury.
  2. Discuss and evaluate the concepts of renal functional reserve and renal failure.
  3. Identify and classify the clinical indicators of renal failure, and evaluate the limitations of these indicators.
  4. Identify the causes of death associated with renal failure with an emphasis on pathogenesis.
  5. Identify, compare, and evaluate the different mechanisms of azotemia.
  6. Discuss and understand the pathogenesis and pathophysiology of uremic syndrome.

1,6

 

 

1,7

 

1,7

 

 

1,6

 

 

2

 

1,3,6,7

26

Urinary (2)

  1. Recognize, compare, and contrast the pathophysiology of acute renal failure and chronic kidney disease.
  2. Identify and understand the types of injury and the defense mechanisms for each compartment of the kidney and each part of the nephron.
  3. Evaluate and understand how the glomerulus, tubules, interstitium, and renal 

    vasculature respond to injury (basic pathogenesis). 

  4. Evaluate and understand the pathophysiology of glomerular disease.

1,3,7

 

 

1,6

 

 

1,6

27

Urinary (3)

  1. Review the structure and function of the lower urinary tract with emphasis on vulnerabilities to injury and defense mechanisms.
  2. Recognize and evaluate the responses to injury and lesion development within the lower urinary tract (pathogenesis).
  3. Identify and evaluate the congenital diseases of the urinary system.
  4. Evaluate and understand the pathogenesis and pathophysiology of renal glomerular disease.
  5. Recognize which diseases are associated with the development of immune complex glomerulonephritis in different species.

1,6

 

 

1,3,6

 

 

1,6

 

1,3.6,7

 

 

6,8

28

Urinary (4)

  1. Evaluate and understand the pathogenesis and pathophysiology of renal tubular diseases.
  2. Identify and evaluate the most common nephrotoxins for different species of domestic animals and describe the pathophysiology for each.
  3. Evaluate and understand the pathogenesis and pathophysiology of diseases of the renal pelvis.
  4. Evaluate and understand the pathogenesis and pathophysiology of diseases of the renal interstitium.
  5. Classify the different types of neoplastic tumors of the kidney and lower urinary tract.
  6. Classify and evaluate the pathophysiology of congenital developmental anomalies of

the lower urinary tract.

1,3,6,7

 

 

1,7

 

 

1,3,6,7

 

 

1,3,6,7

 

 

1,6

 

1,7

11129

Urinary (5, 6)

  1. Evaluate and understand the pathogenesis and pathophysiology of urinary disease in horses.
  2. Evaluate and understand the pathogenesis and pathophysiology of urinary disease in ruminants.
  3. Evaluate and understand the pathogenesis and pathophysiology of urinary disease in pigs.

6,7,8

 

 

6,7,8

 

 

6,7,8

 

 

  1. Evaluate and understand the pathogenesis and pathophysiology of urinary disease in cats.
  2. Evaluate and understand the pathogenesis and pathophysiology of urinary disease in dogs.

6,7,8

 

 

6,7,8

30

Hepatobiliary (1)

  1. Review liver physiology and examine which structures of the liver are most vulnerable to various types of injury.
  2. Examine the different zones of the hepatic lobule and evaluate which zones are more susceptible to certain injuries. Recognize the morphologic features of zonal hepatic necrosis.
  3. Discuss and evaluate the concepts of hepatic functional reserve and hepatic failure.
  4. Evaluate and understand how the liver responds to various types of injury (basic pathogenesis).
  5. Review and classify the different causes of hyperbilirubinemia.
  6. Identify the clinical indicators of hepatic failure.
  7. Evaluate and understand the pathogenesis and pathophysiology of congenital liver diseases.
  8. Compare and contrast the pathogenesis and pathophysiology of acute and chronic hepatitis and cholangitis.
  9. Compare and contrast the pathogenesis of extrahepatic and intrahepatic cholestasis.

1,6

 

 

6

 

 

 

7

 

3,6

 

 

6,7

 

6,7

 

6,7

 

 

6,7

 

 

6

31

Hepatobiliary (2)

  1. Evaluate and understand the pathogenesis and pathophysiology of the four types of circulatory disorders of the liver.
  2. Evaluate and understand the pathogenesis and pathophysiology of liver diseases resulting from hepatocellular accumulations (lipid, glycogen, amyloid, copper, bile pigment, lysosomal

dysfunction).

1,3,6,7

 

 

1,3,6,7

32

Hepatobiliary (3)

  1. Evaluate and understand the pathogenesis and pathophysiology of the most common infectious hepatopathies (viral, bacterial, fungal, protozoal, and parasitic)
  2. Evaluate and understand the basic pathogenesis of hepatotoxicity.

1,3,6,7

 

 

1,3,6

 

 

3. Identify the most common causes of hepatotoxicity in various domestic animal species and understand the

pathophysiology of acute and chronic liver toxicity.

1,6,7,8

33

Hepatobiliary (4)

  1. Classify and evaluate the most common types of primary and metastatic liver neoplasia.
  2. Evaluate and understand the pathogenesis and pathophysiology of hepatic disease in horses.
  3. Evaluate and understand the pathogenesis and pathophysiology of urinary disease in ruminants.
  4. Evaluate and understand the pathogenesis and pathophysiology of urinary disease in pigs.

1,6

 

 

6,7,8

 

 

6,7,8

 

 

6,7,8

34

Hepatobiliary (5)

  1. Evaluate and understand the pathogenesis and pathophysiology of urinary disease in cats.
  2. Evaluate and understand the pathogenesis and pathophysiology of urinary disease in dogs.
  3. Evaluate and understand the pathogenesis and pathophysiology for diseases of the exocrine pancreas.

6,7,8

 

 

6,7,8

 

 

6,7

35

Alimentary (1)

  1. Review the structure and function of the oral cavity.
  2. Review the defense mechanisms of the oral cavity.
  3. Evaluate and understand the pathogenesis and pathophysiology for diseases of the oral cavity including developmental anomalies, erosive and ulcerative disease, gingivitis and stomatitis, viral and bacterial diseases, and oral neoplasia.

1,6

 

6

 

1,3,6,7

36

Exam Review

NA

NA

37

Alimentary (2)

  1. Review and understand normal tooth development and histogenesis.
  2. Evaluate and understand the pathogenesis and pathophysiology for diseases of the teeth, tonsils, salivary gland, tongue, and esophagus.

1,6

 

1,6,7

38

Alimentary (3)

  1. Identify and understand the pathogenesis and pathophysiology for diseases of the rumen, reticulum, abomasum, and stomach.

1,3,6,7

39

Alimentary (4)

  1. Review the structure and function of the intestinal tract.
  2. Review and evaluate the defense mechanisms of the intestine.
  3. Describe and classify intestinal obstructions, displacements, intussusception, and herniation.
  4. Evaluate and understand the pathogenesis and pathophysiology of intestinal diseases: developmental anomalies, megacolon, ileus, lymphangiectasia.

1,6

 

6

 

1,3,6

 

 

1,3,6,7

40

Alimentary (5)

  1. Evaluate and understand the pathogenesis and pathophysiology of viral enteropathies.
  2. Evaluate and understand the pathogenesis and pathophysiology of bacterial enteropathies.
  3. Review and classify the most common intestinal neoplasia of domestic animals.

1,3,6,7

 

1,3,6,7

 

1,3,6,7

41

Alimentary (6)

  1. Evaluate and understand the pathogenesis and pathophysiology for alimentary diseases of the horse.
  2. Evaluate and understand the pathogenesis and pathophysiology for alimentary diseases of ruminants.

6,7,8

 

 

6,7,8

42

Alimentary (7)

  1. Evaluate and understand the pathogenesis and pathophysiology for alimentary diseases of the pig.
  2. Evaluate and understand the pathogenesis and pathophysiology for alimentary diseases of dogs and cats.
  3. Evaluate and understand the pathogenesis and pathophysiology for diseases of the peritoneum, omentum, and mesentery.

6,7,8

 

 

6,7,8

 

 

6,7

43

Integumentary (1)

  1. Review and examine the structure and function of the skin.
  2. Review and examine defense mechanisms of the skin.
  3. Review and evaluate the steps of skin regeneration and repair.
  4. Identify and evaluate the responses of the epidermis to injury.

1,6

 

6

 

1,6

 

1,6

44

Integumentary (2)

  1. Identify and evaluate the responses of the epidermis to injury (cont.).
  2. Identify and evaluate the responses of the dermis to injury.
  3. Identify and evaluate the responses of the adnexa to injury.

1,6

 

1,6

 

1,6

45

Integumentary (3)

  1. Identify, examine, and evaluate congenital and hereditary skin diseases.
  2. Identify, examine, and evaluate skin diseases caused by actinic injury, physical injury, and chemical injury.

1,6

 

1,6

46

Integumentary (4)

  1. Identify, compare, and classify the four types of endocrine-associated dermatopathy.
  2. Identify, compare, and evaluate immune mediated skin diseases – hypersensitivity, autoimmune diseases.

1,6,7

 

1,6,7

47

Integumentary (5)

  1. Identify, compare, and evaluate immune mediated skin diseases – autoimmune diseases (cont.).
  2. Identify, compare, and evaluate the most important viral skin diseases.
  3. Recognize the associated skin lesions and analyze the pathogenesis of infection with poxviruses, herpesviruses, and papillomaviruses.

1,3,6

 

 

1,6

 

1,3,6

48

Integumentary (6)

  1. Identify, compare, and evaluate the most important bacterial skin diseases.
  2. Evaluate the mechanisms by which systemic infections can result in cutaneous lesions and list the most common examples.
  3. Recognize the associated lesions and analyze the pathogenesis of bacterial skin infections.

1,6

 

6,7

 

 

3,6

49

Integumentary(7)

  1. Identify, compare, and evaluate the most important fungal and parasitic skin diseases.
  2. Recognize the associated lesions and analyze the pathogenesis of fungal and parasitic skin diseases.

1,6

 

3,6

50

Integumentary (8)

  1. Review the basic mechanisms of oncogenesis.
  2. Review the significance of tumor cell morphology as it relates to accurate diagnosis of skin neoplasia.
  3. Recognize and compare the morphologic features that distinguish benign neoplasia from malignant neoplasia.

1,6

 

6

 

 

3,6

51

Integumentary (9)

  1. Identify, compare, and evaluate the most important neoplastic skin diseases in domestic animals.

1,6

 

 

1,6,7

 

 

  1. Analyze and evaluate the importance of histologic grading using the example of canine mast cell tumors.
  2. Apply the differentiating features of benignancy and malignancy as it relates to common skin tumors.
  3. Recognize and examine paraneoplastic conditions.

 

 

1,6

 

 

6,7

52

Integumentary(10)

  1. Review, compare, and evaluate the morphology and pathogenesis of skin disease.
  2. Review the tissue response to skin injury as it relates to lesion development.
  3. Analyze and compare the different types of skin lesions.
  4. Recognize the different patterns of lesions that distinguish specific skin diseases.

1,3,6

 

1,6

 

1,6

 

1,6

53

Exam Review

NA

NA

Lab.

Topic

Learning Outcomes

CLO

1

Inflammation – case-based active learning

  1. Evaluate gross tissues for inflammatory lesions.
  2. Propose the pathogenesis of disease.
  3. Determine the likely clinical outcome.

3,6

 

6

7

2

Neoplasia – case- based active learning

  1. Be able to recognize and describe the main microscopic features that characterize hyperplasia and benign and malignant tumors.
  2. Given the cell of origin and a description (gross and microscopic) of a tumor, be able to correctly name the tumor.
  3. Given a signalment, history and written histopathology report involving a tumor, be able to distinguish between benign and malignant tumors.
  4. Be able to distinguish between the tumor parenchyma and stroma.

6

 

 

2,3,6

 

 

2,3,6

 

 

2

Alignment of Course Learning Outcomes with Program Learning Outcomes

CLO

SVM Program Level Outcome (PLO)

1

Core clinical competency. PLO 2, 3, 4, 20.

2

Core clinical competency and medical knowledge. PLO 2, 3, 4.

3

Core clinical competency. PLO 2, 3, 4, 20.

4

Core clinical competency and medical knowledge. PLO 3, 4, 6, 20.

5

Core clinical competency. PLO 6, 20.

6

Core medical knowledge. PLO 3, 4, 6.

7

Core clinical competency. PLO 3, 4, 6, 20.

8

Core medical knowledge. PLO 3, 4, 6.

Course Schedule

Week

Date

Daily Lectures/Lessons

Weekly Assignments

Office

Hours

 

 

 

 

 

1

Jan 17

Lec 1 - Intro to pathology – Butler

 

 

 

Jan 18

Lec 2 - Cell injury and death 1 - Butler

No assignments

 

Jan 19

No lecture

 

 

Jan 20

No Lecture

 

 

Jan 21

Lec 3 - Cell injury and death 2 – Butler

 

2

Jan 24

Lec 4 - Vascular disorders – Wilkerson

 

 

 

 

Jan 25

 

Lec 5 – Hemostasis Congestion – Wilkerson

 

No assignments

Zoom Office

Hours

Butler/Wilk

 

Jan 26

Lec 6 - Inflammation 1 – Marancik

 

 

 

 

 

 

TBA

 

Jan 27

Lec 7 - Inflammation 2 – Marancik

 

 

 

 

 

 

Optional

 

Jan 28

Lec 8 - Inflammation 3 – Marancik

 

 

3

Jan 31

Lec 9 – Inflammation 4 - Marancik

 

 

 

 

Feb 1

 

Feb 2

Lec 10 – Inflammation 5 - Marancik No lecture

Case Study Assignment 1

(Sakai – 1 pt)

Deadline: Thursday Feb 3, 11:55 pm

Zoom Office

Hours

Marancik

 

 

 

 

TBA

 

Feb 3

Lec 11 - Inflammation 6, Case Study

Marancik

 

 

Optional

 

Feb 4

 

 

 

 

 

Lec 12 - Inflammation 7 – Marancik

 

 

4

Feb 7

Independence Holiday

 

 

 

 

 

Case Study Assignment 2

Zoom Office

 

Feb 8

Lec 13 – Inflammation 8 - Marancik

(Sakai – 1 pt)

Hours

 

 

 

Deadline: Wednesday Feb

Marancik

 

Feb 9

Lec 14 - Inflammation 9, Case Study -

9, 11:55 pm

 

 

 

Marancik

 

TBA

 

Feb 10

 

Laboratory: Tuesday,

 

 

 

Lec 15 - Neoplasia 1 – Butler

February 8th or Thursday,

Optional

 

Feb 11

 

February 10th, 8:30 am

 

 

 

Lec 16 – Neoplasia 2 - Butler

(Micro Lab)

 

5

Feb 14

 

Feb 15

 

Feb 16

Lec 17 - Neoplasia 3 – Butler

Lec 18 - Neoplasia 4 – Butler No lecture

 

Neoplasia Lab Assignment: Tumor Nomenclature (Sakai – 2 pts)

 

 

Feb 17

 

Feb 18

Lec 19 – No lecture (Neoplasia 1-4 only)

 

Lec 20 – Integumentary 1 – Butler

*Deadline Sunday Feb 20th, 11:55 pm

 

6

Feb 21

Lec 21 - Integumentary 2 - Butler

 

 

 

 

 

Dermpath Lab

Zoom Office

 

Feb 22

Lec 22 - Integumentary 3 - Butler

Assignment:

Hours

 

 

 

Patterns of Skin Lesions

Butler

 

Feb 23

Lec 23 - Integumentary 4 - Butler

(Sakai – 2 pts)

 

 

 

 

*Deadline Sunday Feb

TBA

 

Feb 24

No lecture

27th, 11:55 pm

 

 

 

 

 

Optional

 

Feb 25

Lec 24 - Integumentary 5 – Butler

 

 

7

Feb 28

Lec 25 - Integumentary 6 - Butler

 

 

 

 

Mar 1

 

Lec 26 - Integumentary 7 – Butler

Zoom Office

Hours

Butler

 

Mar 2

Lec 27 - Integumentary 8 - Butler

 

 

 

 

TBA

 

Mar 3

No lecture

 

 

 

 

Optional

 

Mar 4

Lec 28 - Integumentary 9 – Butler

 

8

MIDTERMS

Week

 

Mar 7

 

Midterm Exam – Mon 12:00 noon (40 pts)

 

 

 

Mar 8

 

 

Mar 9

 

 

Mar 10

 

 

Mar11

 

 

 

 

 

 

9

 

Urinary Pathology (Week 1/2)

 

 

 

Mar 14

No class (ClinPath Midterm Exam)

 

 

 

 

 

 

Zoom Office

 

Mar 15

TopHat Lesson 1 (2 pts)

 

Hours

 

 

 

 

Butler

 

Mar 16

TopHat Lesson 2 (2 pts)

***Must complete all

 

 

 

 

TopHat Lessons by

TBA

 

Mar 17

TopHat Lesson 3 (2 pts)

deadline Sunday Mar

 

 

 

 

20th, 11:55 pm. Late

Optional

 

Mar 18

Review TopHat Lessons 1-3

lessons will not receive

 

 

 

 

points.

 

 

 

Expected time commitment = 4 hours

 

 

10

 

 

Mar 21

Urinary Pathology (Week 2/2)

 

Time for Review Papers

 

 

Reading Assignment

 

 

 

Mar 22

 

Mar 23

 

Mar 24

 

 

 

Mar 25

Time for Review Papers and Lesson Review Time for TopHat Lab Assignment (morning) Live Review Session with exam practice

Thursday at 10:30 am (2 hours)

Attendance is mandatory.

 

No class

 

 

 

Expected time commitment = 6 hours

Review Papers 1 - 3

 

 

Urinary Lab Assignment TopHat Virtual Necropsy (2 pts)

 

***Must complete all lab and reading assignments by deadline Wed Mar 23rd, 11:55 pm. Late assignments will not receive points.

 

 

 

Zoom Office Hours – Butler

 

TBA

 

Optional

11

 

Hepatobiliary and Exocrine Pancreas

 

 

 

 

(Week 1/2)

 

 

 

Mar 28

TopHat Lesson 1 (2 pts)

 

 

 

 

 

 

Zoom Office

 

Mar 29

TopHat Lesson 2 (2 pts)

***Must complete all

Hours

 

 

 

lessons by deadline

Butler

 

Mar 30

TopHat Lesson 3 (2 pts)

Sunday Apr 3rd, 11:55 pm.

 

 

 

 

Late lessons will not

TBA

 

Mar 31

TopHat Lesson 4 (2 pts)

receive points.

 

 

 

 

 

Optional

 

Apr 1

Time for Lessons Review

 

 

 

 

Expected time commitment = 5 hours

 

 

12

 

Hepatobiliary and Exocrine Pancreas

 

 

 

 

(Week 2/2)

Reading Assignments

 

 

 

Review Paper 1

 

 

Apr 4

Time to read Review Papers

Review Paper 2

 

 

 

 

Review Paper 3

 

 

Apr 5

Time for Review Papers and Lesson Review

 

Zoom Office

 

 

 

Liver Lab Assignment

Hours

 

Apr 6

Time for Lab Assignment (morning)

TopHat Virtual Necropsy

Butler

 

 

 

(2 pts)

 

 

Apr 7

Live Review Session with exam practice

 

TBA

 

 

Thursday at 10:30 am (2 hours)

***Must complete lab

 

 

 

Attendance is mandatory.

and reading assignments

Optional

 

 

 

by deadline Wed Apr 6th,

 

 

Apr 8

No class

11:55 pm. Late

 

 

 

 

assignments will not

 

 

 

Expected time commitment = 6 hours

receive points.

 

13

 

 

Apr 11

 

Apr 12

Alimentary Pathology (Week 1/2)

 

TopHat Lesson 1 (2 pts)

 

TopHat Lesson 2 (2 pts)

 

 

***Must complete all lessons by deadline Sunday Apr 17th, 11:55

 

 

Apr 13

 

Apr 14

 

Apr 15

TopHat Lesson 3 (2 pts)

 

TopHat Lesson 4 (2 pts)

 

Good Friday Holiday. No class.

 

Expected time commitment = 4 hours

pm. Late lessons will not receive points.

 

14

 

Alimentary Pathology (Week 2/2)

 

 

 

 

Reading Assignment

 

 

Apr 18

Easter Monday. No class.

Review Paper 1

 

 

 

 

Review Paper 2

Zoom Office

 

Apr 19

Time for Review Papers and Lesson Review

 

Hours

 

 

 

Alimentary Lab

Butler

 

Apr 20

Time for Lab Assignment (morning)

Assignment

 

 

 

 

TopHat Virtual Necropsy–

TBA

 

Apr 21

Live Review Session with exam practice

Diarrheal Disease (2 pts)

 

 

 

Thursday at 10:30 am (2 hours)

 

Optional

 

 

Participation is mandatory.

***Must complete all

 

 

 

 

assignments by deadline

 

 

Apr 22

No class

Wednesday Apr 20th,

 

 

 

 

11:55 pm. Late

 

 

 

 

assignments will not

 

 

 

Expected time commitment = 5 hours

receive points.

 

15

 

 

 

 

 

Apr 25

Time for Lessons Review and Study

 

 

 

Apr 26

 

No class

Zoom Office

Hours

Butler

 

Apr 27

No class

 

 

 

 

TBA

 

Apr 28

No class

 

 

 

 

Optional

 

Apr 29

No class

 

16

FINAL

Exams

 

May 2

 

Labor Day

 

 

 

May 3

 

 

May 4

 

 

May 5

 

 

May 6

Final Exam – Friday 12:00 pm (50 pts)

17

FINAL

Exams

 

 

 

 

18

CAPPS

 

 

 

 

Grading and Assessment Policy

All students are expected to be familiar with the examination guidelines issued by the office of the Dean of the School of Veterinary Medicine. Please refer to the Student Manual for details.

  • Grading scale. Please refer to the SVM Student Manual.
  • Types of assessment.
    • There will be two written examinations and nine assignments/lessons for this course. Please see schedule above.
    • Assignments and Lessons will NOT be accepted late. Late submissions will result in 0 points. Deadlines are indicated in the above schedule.
    • Please use the CHECKLISTS in the above schedule to keep up with weekly Assignments and Lessons.
    • The written examinations will consist of multiple-choice questions (MCQ’s) administered through ExamSoft. The examinations will cover the material described in the lectures, study outlines, laboratory sessions, out-of-class lessons, and reading assignments.
  • Assessment breakdown:

 

Points

Case Study 1 – Inflammation

1

Case Study 2 – Inflammation

1

Lab Assignment – Neoplasia

2

Lab Assignment – Dermatopathology

2

Midterm Exam

40

Urinary Lessons (3)

6

Lab Assignment – Urinary dz

2

Hepatobiliary Lessons (4)

8

Lab Assignment – Liver dz

2

Alimentary Lessons (4)

8

Lab Assignment – Diarrheal dz

2

Final Exam

50

Total points

124

Recommended Study Strategies
  • Know the syllabus.
  • Know the learning outcomes for each lecture, lab, and assignment.
  • Pre-read material before lectures and labs and be sure to know all new vocabulary before class.
  • Be sure to complete all out-of-class lessons and assignments prior to in-class sessions with instructor (applies to flipped classroom – systems pathology).
  • Learning through repetition is key for long-term retention.
    • Pre-read material, then attend lectures, then self-study, then group study, then final review
  • Participate in class and ask questions when you do not understand something. Use the Forums application in My Courses (Sakai) to ask questions about course content.
  • Attend DES groups and review sessions.
  • Request Office hours for any further needed clarification about course concepts.
Instructor's Expectations of the Student

The student is expected to review learning outcomes and provided course content BEFORE the scheduled lectures and laboratory sessions/assignments. Every student is expected to participate in active learning assignments, exercises, and prescribed readings. All students are expected to complete all lessons and assignments prior to in-class sessions.

Professionalism Statement

Please refer to SVM Student Manual.

Attendance/Participation Policy

(In compliance with SGU and SVM assessment guidelines.)

Students are expected to be available during the standard 8-5am AST school day, to attend, engage with in-person/online content, and participate in all classes and clinical rotations for which they have registered. Employment is not an excusable absence. Although attendance, engagement, and participation may not be recorded at every academic activity, attendance, engagement, and participation is graded for mandatory sessions. Students’ lack of attendance, engagement, and participation may adversely affect their academic status as specified in the grading policy.

If failure to attend, engage, or participate in individual classes, examinations, and online activities, or from the University itself is anticipated, or occurs spontaneously due to illness or other extenuating circumstances, proper notification procedures must be followed.

Lecture attendance policy: Attendance is strongly recommended and expected.

Laboratory session attendance policy: Attendance is mandatory and required to receive credit for the laboratory sessions. Any absence from lab sessions requires the necessary documentation from the Dean of Students Office. Please contact the Dean of Students Office directly of details and procedures. Any unexcused absence may lead to failure of the course at the discretion of the Course Director.

Policy Regarding Missing Examinations and/or Failure of Submission of Assignments

Students who fail to attend an examination (Sakai quiz/test or Examsoft) or submit an assignment by the deadline without a valid reason (see student manual: SGUSVM POLICY ON AN EXCUSED ABSENCE (EA) FOR STUDENTS) will receive a score of “0” points for the examination.

Students who have technical issues during the examination MUST inform the Course Director (bbutler@sgu.edu) and IT (tellexaminationservices@sgu.edu OR support@sgu.edu OR call 1-631-665-8500 ext. 4444 (US, NU, International) OR 1- 473-439-2000 ext. 4444 (Grenada), AND Dean of Students (DOS@sgu.edu) during the open period for the examination. Failure to do so immediately will result in the student receiving the highest score recorded at the time, but NOT being eligible to take a completion examination.

Scheduling of examinations (regular, re-sit, completion, comprehensive, or exemption) is at the discretion of the University.

ExamSoft Policy

All students are responsible for knowing and complying with the University’s Code of Conduct and the guidelines. Students must read and then sign the Honor Code statement at the start of examinations to indicate that they will comply with the University Code of Conduct.

Prior to Exam Day

  1. Each student is required to have a laptop for the purpose of taking computer- based examinations (e-Exams) at SGU. Students must ensure that their laptops meet the current minimum system requirements prior to exam day:
  2. Examinees must use their MY SGU Member Center username and password to access the Custom Home Page (www.examsoft.com/sgu) created by ExamSoft for the University.
  3. Examinees are responsible for downloading and registering the latest version of Examplify on their laptop prior to exam day. Once Examplify has been successfully downloaded, examinees are strongly encouraged to familiarize themselves with the software by downloading and taking practice exams.
  4. Examinees are responsible for setting their laptop up for ExamMonitor prior to the exam (see links below).
  5. Examinees will be notified via MyCourses, of all exam related information. Email notifications will also be sent from ExamSoft Support to examinees, notifying them of examinations available for downloading.
  6. Examinees experiencing difficulties with their laptop are encouraged to visit the IT department for assistance prior to exam day. Examinees needing a laptop must visit the Office of Institutional Advancement (OIA) to request an exam loaner.
  7. Examinees should visit the following information to familiarize themselves with the online proctored exam format and set up their baseline photo.
    1. A Examsoft/ExamID quick guide for students (Please note that the current Examplify version is 2.3.8)
    2. The Examsoft student perspective video 30mins
    3. The Examsoft/ExamID FAQ
    4. Examsoft information page
    5. The general Reminders/Guidelines
Copyright Policy

The materials (such as slides, handouts and audio/video recordings) provided to students who are taking courses at St. George’s University (SGU) are the intellectual property of the Faculty and/or Administration of SGU. Students are free to use these materials solely for the purpose of group or individual study. Reproduction in whole or in part is prohibited.